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Size exclusion chromatography combined with multi-angle light scattering (SEC-MALS) has become a powerful analytical approach for characterizing biomolecules under native conditions. It enables direct measurement of molar mass, aggregation, fragment profiles, and conjugation ratios — without relying on column calibration assumptions. In a recent technical session hosted by Venture Center’s bioanalytical facility, experts demonstrated how SEC-MALS strengthens workflows for monoclonal antibodies, biosimilars, antibody-drug conjugates (ADCs), antibody-oligonucleotide conjugates (AOCs), glycoproteins, pegylated proteins, and peptide therapeutics. The method supports both research and quality workflows by delivering absolute molar mass and composition data in a single run. Read more
Flow cytometry has become a central analytical technique for researchers studying complex and heterogeneous cell populations. By allowing cells to flow one by one through a focused laser beam, the technology captures both physical characteristics—such as size and granularity—and molecular signatures revealed through fluorescence. This combination of speed, sensitivity, and multiparametric capability makes flow cytometry especially powerful for identifying specific cell subsets, evaluating functional states, and monitoring cell health under different experimental conditions. Read more
The rise of biologics and biosimilars has transformed drug development, bringing forward new therapies like monoclonal antibodies (mAbs) and insulins. Yet, ensuring their quality and regulatory approval hinges on a key component: cell-based functional assays (CBFAs). In this blog, we highlight insights from Venture Center’s session on how CBFAs function as critical quality attributes (CQAs) in biologics development and biosimilar approval. Read more
Targeted mass spectrometry (MS) has become a central technique in translational biology, bridging fundamental discovery work and real-world clinical validation. By allowing precise quantification of specific proteins, peptides, and metabolites, targeted MS helps answer critical biological questions, especially in metabolic and lifestyle diseases like diabetes. Read more
Explore biophysical characterization tools for monoclonal antibodies, biosimilars, and complex biologics. Learn how CBA in India supports structural analysis, aggregation, glycan profiling, and mass spectrometry. Read more
Antibody-based immunotherapies have transformed treatment for cancer, autoimmune diseases, and infections. Key to their action are Antibody-Dependent Cellular Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC). This blog explores the science behind these mechanisms and how CBA supports their testing and validation in India. Read more
