Scientists at NCCS have developed a novel tumor cell co-culture protocol and system for understanding the role of glioma stem cells (GSC) in mediating tumor functions in Glioblastoma (GBM). GBM is a highly invasive malignant tumor with high incidence of therapy resistance and tumor relapse after surgery. This relapse is due to repopulation of tumor by GSCs and is characterized by existence of GSCs in close proximity with endothelial cells (EC). In order to study the GSC-EC interactions, this innovative self-propagating GSC-EC co-culture system was developed as a highly replicating in-vitro model of GBM. Continue reading
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