Interfering with Immune Cell Mobilization in Autoimmune Conditions

How do immune cells overcome the brain defence causing multiple sclerosis? What triggers mobilization of immune cells from the secondary immune organs in inflammatory bowel disease? In order to find answers to the occurrences in these autoimmune conditions, scientists at NCCS are studying the mechanism of cell signaling at the site of inflammation and subsequent immune cell mobilization. Their research is aimed at identifying potential ways to manage autoimmune conditions by either blocking the signalling that leads to inflammation, manipulating the mobilization of immune cells or enhancing the activity of regulatory or suppressor cells in modulating the immune system. Potential use of this research would be in developing therapies for autoimmune conditions.

autoimmune

Reference:

  • Role of tumor necrosis factor superfamily (TNFSF) in neuroinflammation and autoimmunity, Frontiers in Immunology 2015, 6:364 (Article).
  • Role of gamma-delta (γδ) T cells in the autoimmunity, Journal of Leukocyte Biology 2015), 97(2):259-271 (Article).
  • Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance, Frontiers in Genetics  2013, 4:8 (Article).

 Technology Readiness: TRL B1/B2

Technology Status: Proprietary Know-how

Technology Availability: Know-how available for co-development and/or sponsored projects.