Endocytosis in deciding fate of Embryonic Stem Cells

Scientists at NCCS are investigating the role of endocytosis and vesicular transport in deciding the future state of an undifferentiated embryonic stem cell. Using experimental techniques like large scale siRNA screening, reprogramming assays and biophysical manipulation of mouse embryos, they are studying how modifications to cellular or vesicular transport determines whether an embryonic stem cell maintains pluripotency or differentiates into a specific cell type.


Figure 1: Schematic of siRNA screen to knockdown genes involved in
endocytosis in mouse embryonic stem cells.

Further studies are ongoing to learn how cellular or vesicular transport differs in embryonic stem cells and differentiated cells. Potential application of this research is in understanding early embryonic development.


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Technology Readiness: TRL A

Technology Status: Proprietary Know-how

Technology Availability: Know-how available for co-development.