Using the pluripotent embryonic stem cells as a model system, scientists at NCCS are investigating the epigenetic factors and molecular determinants which are involved in deciding and controlling differentiation of stem cells into specific cellular lineages. They are using a live reporter based cell trapping approach for monitoring the development of embryonic stem cells into cardiac and neuronal cells.
Some of the potential applications envisioned are drug screening, pharmacogenomics, gene therapy, cell therapy and tissue engineering applications.
- Temporal and Contextual Orchestration of Cardiac Fate by WNT-BMP Synergy and Threshold, J Cell Mol Med, 2010 Aug; 14(8): 2094–2108 (Article).
- Notch Exhibits Ligand bias and Maneuvers Stage Specific Steering of Neural Differentiation in ESCs. Cell. Biol. 2010 Apr; 30(8):1946-1957 (Article).
- Neural induction from ES cells portrays default commitment but instructive maturation, PloS One 2007 Dec 19;2(12):e1349 (Article).
Technology Readiness Level: TRL B1
Technology Status: Proprietary Know-how
Technology Availability: Know-how available for co-development and for conducting sponsored research.