Scientists at NCCS have developed a novel platform for screening of potential anti-tumor agents, compounds and extracts, based on 3-dimensional Multi-Cellular Spheroids derived from tumor cells and prostate apoptosis response (PAR)-4 indicator that is linked to cell death.
PAR-4 is identified to aid in drug-induced death in resistant glioma stem cells and has potential application in overcoming problems of drug resistance in cancers treatment.
Technology Readiness: TRL B1 (In-vitro efficacy/ results demonstrated)
Technology Status: Proprietary Know-how
Technology Availability: Know-how available for co-development with partners.
- Secretory prostate apoptosis response (Par)-4 sensitizes multicellular spheroids (MCS) of glioblastoma multiforme cells to tamoxifen-induced cell death. FEBS Open Bio 5 (2015) 8–19 (Article).
- Expression and Regulation of Prostate Apoptosis Response-4 (Par-4) in Human Glioma Stem Cells in Drug-induced Apoptosis, PLoS ONE 9(2): e88505, doi:10.1371/ journal.pone.0088505 (Article).